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It's good to have a broad mix of subjects that will keep you interested. If you enjoy what you are doing it will make it so much easier when the pressure's on. Although, if you do want to do pharmaceutical degree, you're probably best doing advanced maths, as opposed to general.

To the best of my knowledge (more accurately, based on the information provided by my teacher) you can do either. This will depend on the focus of your investigation - is change and continuity a key element?