i have an assignment where i gotta DESCRIBE progress in the research towards production of artificial blood and EXPLAIN why such research is needed.......thank u!
Blood substitutes, often called artificial blood, are used to fill fluid volume and/or carry oxygen and other blood gases in the cardiovascular system. Although commonly used, the term is not accurate since human blood performs many important functions.
A significant breakthrough in progression towards a development of artificial blood occurred in 1883 with “Ringers Solution”. It contained sodium, potassium, calcium salts and lactate. The solution could restore blood pressure after blood loss but could not replace the action of R.B.C’s. The first suggestion for artificial blood was made shortly after William Harvey first described circulation of blood, in 1616. At this time they though that artificial blood could be made from wine or milk. It was at first thought that isolated haemoglobin could be used as a blood substitute because it has a higher oxygen carrying capacity; this isn’t an option yet because, in isolation toxic changes occur to haemoglobin. Currently work is being done to stabilise isolated haemoglobin and make it safe to use. 1966 experiments with mice uncovered a new type of artificial blood, perflurocarbons. These are long chained polymers similar to Teflon; composed of readily and reliable materials, this ensures adequate supply for a large scale use of the artificial blood.
Advantages of using blood substitutes-
They are free of infectious agents and allergens, making them non-toxic and disease free.
They do not need refrigeration for storage and can be kept for a longer period. Eg, 2-3 years compared to 3 weeks for human blood.
There is universal acceptance by all groups allowing transfusion to a person without any tests.
It is readily available in large supplies, solving the world wide problem of blood donors.
Disadvantages of using blood substitutes-
They are only designed to carry oxygen and carbon dioxide
They are not involved in clotting, coagulation and immune defence.