http://en.wikipedia.org/wiki/Nihilism
How = techniques. Look at how the plot devices, dramatic techniques and the linguistics (language techniques) communicate and develop the nihilistic aspects to the responder.
The whole idea of Nihilism is that life has no meaning or purpose. It can then be interpreted that Macbeth incorporates Nihilistic values as he loses the plot and craves more and more power. If life is meaningless to Macbeth his morals and ethics are annihilated (unintentional pun) and he can do whatever he pleases, regardless of the consequences.