The primitive or antiderivative is a function whihc differentiated would yield the original function. An integral is the summation of the f(x).delta_x where delta_x -> 0 (also representing the signed area under the curve). When certain conditions hold, the fundamental theorem of calculus says that the primitive and the integral of a function are the same. (basically, if the function is continuous and differentiable). Thus, you can find the integral by antidifferentiating.
A case where it doesn't hold, for example, find the area under the curve f(x) = 1/x, from x=-1 to x=1. The function is not continuous at x=0, so you cannot apply the fund thm of calculus, ie you can't say the area is INT (from x=-1 to x=1) [dx/x].